Back in 1998, the federal government mandated that wheat flour be fortified with folic acid because of strong evidence that folic acid deficiency in pregnant women caused neural tube defects, including spina bifida. It worked, reducing neural tube defects in babies by a whopping 35% nationwide. But not everyone benefited equally, because not all communities consume wheat flour at the same rate.
The Latino community, in particular, relies much more on corn masa than wheat flour. Only one in four Hispanic Californian women report taking daily folic acid supplements in the month before pregnancy, which is the most critical window since the neural tube forms so early. As a result, neural tube defects (NTDs) are more than twice as common in Hispanic versus non-Hispanic infants in California.
California’s move to fortify corn masa is designed to close that gap and protect babies who were largely missed by the original policy.
But there’s a lot of concern on social media about something called the MTHFR gene, and whether this change is safe for people who have it. It’s a hot topic on social media and podcasts like Joe Rogan, and HHS Secretary RFK Jr. has expressed displeasure, as well. People are asking if it affects people with this gene differently, if it’s safe long-term, and if they should still eat corn tortillas.
Here’s what we know: MTHFR variants are very common and may affect up to half of the U.S. population, including a higher share of Hispanic individuals. People with these variants can still process folic acid and other forms of folate, just slightly less efficiently. Importantly, folic acid is still proven to prevent NTDs, even in people with MTHFR variants, and remains safe. Other forms of folate may be marketed as “better,” but folic acid is the only one with strong evidence behind it for preventing birth defects.
So, while you’re not wrong to have questions, you can rest assured that this is a sound scientific policy that’s safe. We have decades of evidence from wheat products to prove it. Restaurants are in the clear to keep the corn tortillas on the menu, but in California, be prepared to face a few more questions than usual.
Sources: YLE, YLE California, Fox, March of Dimes, NIH
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